dc.contributor |
Robertson, SA |
|
dc.contributor |
Seamark, RF |
|
dc.date.accessioned |
2012-01-30T04:37:19Z |
|
dc.date.available |
2012-01-30T04:37:19Z |
|
dc.date.issued |
1992 |
|
dc.identifier.citation |
Rep. Fert. Dev. (1992) 4(4): 435-448 |
|
dc.identifier.issn |
1031-3613 |
|
dc.identifier.uri |
http://livestocklibrary.com.au/handle/1234/15625 |
|
dc.description.abstract |
Granulocyte-macrophage colony stimulating factor (GM-CSF) is one of a number of lympho-haemapoietic cytokines, including CSF-1, interleukin-6 (IL-6) and leukaemia inhibitory factor (LIF) now known to be synthesized by epithelial cells in the murine uterus. GM-CSF synthesis is regulated primarily by the ovarian steroid hormone oestrogen, but is also subject to modulation by factors including a seminal component of seminal vesicle origin which stimulates a 20-fold increase in luminal fluid content at mating, and bacterial lipopolysaccharide (LPS) and the T-lymphocyte and natural killer (NK) cell product interferon-gamma (IFN gamma). In the non-pregnant mouse GM-CSF synthesis peaks at oestrus. Synthesis is maintained at comparable or moderately higher levels during the preimplantation period of pregnancy and in the non-decidualized endometrium during mid gestation. An embryotrophic activity is suggested by studies in vitro that indicate that GM-CSF stimulates attachment and outgrowth of blastocysts. It is postulated that GM-CSF is of major importance to the physiology of pregnancy through its role as a component of a local cytokine circuit acting to recruit and regulate function of endometrial leukocytes, and by its action as interlocutor and important effector arm in embryo-maternal interactions during gestation. |
|
dc.publisher |
CSIRO Publishing |
|
dc.source.uri |
http://www.publish.csiro.au/?act=view_file&file_id=RD9920435.pdf |
|
dc.title |
Granulocyte-macrophage colony stimulating factor (GM-CSF): one of a family of epithelial cell-derived cytokines in the preimplantation uterus |
|
dc.type |
Research |
|
dc.description.version |
Journal article |
|
dc.identifier.volume |
4 |
|
dc.identifier.page |
435-448 |
|
dc.identifier.issue |
4 |
|