Lack of correlation between conceptual karyotype and maternal response to placentation

Abstract

The placental karyotype was correlated with the morphology of the placentalbed in miscarriages. Abnormal placentation was as likely to be seen in euploidconceptions as in aneuploid conceptions, whereas normal placentation was seenwith both euploid and aneuploid pregnancies. No consistent chromosomalabnormality was found with abnormal placentation. Since abnormal placentationis implicated in the pathogenesis of preeclampsia and miscarriages, thesefindings may be useful with respect to the localization of a candidate‘preeclampsia gene’ by identifying a specific chromosomeassociated with abnormal placentation.