Identification of genes regulated by an interaction between av�3 integrin and vitronectin in murine decidua.

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dc.contributor Mangale, SS
dc.contributor Modi, DN
dc.contributor Reddy, KVR
dc.date.accessioned 2012-01-31T04:19:32Z
dc.date.available 2012-01-31T04:19:32Z
dc.date.issued 2008
dc.identifier.citation Rep. Fert. Dev. (2008) 20(2): 311-319
dc.identifier.issn 1031-3613
dc.identifier.uri http://livestocklibrary.com.au/handle/1234/18172
dc.description.abstract The delicate balance between embryo invasion and suppression of maternal immune rejection requires a fully functional decidua in species with haemochorial placenta. Our understanding of the decidual function is very limited due to the molecular and cellular complexity involved in decidualisation. The cell adhesion molecule ?v?3 integrin and its ligand vitronectin are upregulated in the mouse decidua during mid-pregnancy. The implications of interactions between ?v?3 and vitronectin in regulating decidual function are not known. In the present study, interactions between ?v?3 and vitronectin in the decidual cells of the mouse were blocked in vitro and effects on cell fate were evaluated by studying the differentially regulated genes by cDNA array and real-time polymerase chain reaction (PCR). The results indicate that expression of various genes involved in apoptotic and cell cycle pathways, as well as cytokine receptors, was deranged. Signalling through ?v?3 seems to be important to maintain a balance between cell proliferation and apoptosis, along with the modulation of inflammatory responses of decidual cells.
dc.publisher CSIRO Publishing
dc.source.uri http://www.publish.csiro.au/?act=view_file&file_id=RD07155.pdf
dc.subject cDNA array
dc.subject mouse
dc.subject pregnancy
dc.title Identification of genes regulated by an interaction between av�3 integrin and vitronectin in murine decidua.
dc.type Research
dc.description.version Journal article
dc.identifier.volume 20
dc.identifier.page 311-319
dc.identifier.issue 2


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